31:T8f3,ex_plot = { const this_data = data.ex; const x = "VISITDY"; const y = "EXDOSE"; const one_day = 1000 * 60 * 60 * 24; const trt_start = data.trt_start; const trt_end = data.trt_end; const date_min = data.start; const date_max = data.end; const x_values = produceBreaks(date_min, date_max); const y_values = [0, Math.ceil(d3.max(this_data, (d) => +d[y]) / 10) * 10]; const end_data = [ this_data[this_data.length - 1], { [x]: trt_end, [y]: this_data[this_data.length - 1][y], EXTRT: this_data[this_data.length - 1].EXTRT } ]; const plot = Plot.plot({ width: width, height: 200, marginLeft: 320, marginBottom: 40, className: "ex", x: x_axis(date_min, date_max, x_values), y: { label: `Dose (in ${this_data[0].EXDOSU})`, domain: y_values }, color: { domain: trt_ex, range: [colors.placebo, colors.drug_b] }, grid: true, marks: [ Plot.areaY(this_data, { x: `${x}`, y: `${y}`, fill: "EXTRT", curve: "step-after", opacity: 0.25 }), Plot.areaY(end_data, { x: `${x}`, y: `${y}`, fill: "EXTRT", curve: "step-after", opacity: 0.25 }), Plot.link(this_data, { x1: `${x}`, x2: `${x}`, y1: 0, y2: `${y}`, strokeWidth: 1, stroke: colors.black, strokeDasharray: 4 }), Plot.line(this_data, { x: `${x}`, y: `${y}`, strokeWidth: 3, stroke: "EXTRT", curve: "step-after" }), Plot.line(end_data, { x: `${x}`, y: `${y}`, strokeWidth: 3, stroke: "EXTRT", curve: "step-after", strokeDasharray: 4 }), Plot.dot(this_data, { x: `${x}`, y: `${y}`, r: 4, strokeWidth: 2, fill: "white", stroke: "EXTRT", title: (d) => `Week ${Math.round(d[x] / 7)} \nDose: ${d[y]}mg \n(${d.EXTRT})` // \n makes a new line }), Plot.ruleX([0], { stroke: colors.black }), Plot.ruleY([0], { stroke: colors.black, opacity: d3.max(this_data, (d) => +d[y]) === 0 ? 0 : 1 }) ] }); return plot; }32:Ta88,legend_1 = { const legend = [ { x1: -10, x2: -8, y: 0, label_1: "Start date before window ", label_2: " End date", arrow: false, dot: false, line: true }, { x1: 0, x2: 2, y: 0, label_1: "Start date ", label_2: " End date", arrow: false, dot: true, line: true }, { x1: 10, x2: 12, y: 0, label_1: "Start date ", label_2: " Unknown end date", arrow: true, dot: true, line: true }, { x1: 20, x2: 22, y: 0, label_1: "Serious event ", label_2: "", arrow: false, dot: true, line: false } ]; return Plot.plot({ width: width, marginLeft: 90, marginRight: 120, height: 25, marginBottom: 0, marginTop: 0, className: "ae", x: { label: null, domain: [d3.min(legend, (d) => d.x1) - 2, d3.max(legend, (d) => d.x1) + 2] }, y: { label: "", ticks: 0 }, grid: false, marks: [ Plot.link( legend.filter((d) => d.arrow === false && d.line === true), { x1: "x1", x2: "x2", y1: "y", y2: "y", strokeWidth: 4, stroke: colors.black, opacity: 0.7 } ), Plot.arrow( legend.filter((d) => d.arrow === true && d.line === true), { x1: "x1", x2: "x2", y1: "y", y2: "y", strokeWidth: 4, stroke: colors.black, opacity: 0.7, headLength: 3 } ), Plot.dot( legend.filter((d) => d.dot === true), { x: "x1", y: "y", r: 4, strokeWidth: 2, fill: "white", stroke: colors.black } ), Plot.dot( legend.filter((d) => d.arrow === false && d.line === true), { x: "x2", y: "y", r: 3, fill: colors.black, stroke: "none" } ), Plot.dot( legend.filter((d) => d.line === false), { x: "x1", y: "y", r: 2, dy: -10, fill: colors.black, stroke: "none" } ), Plot.text(legend, { x: "x1", y: "y", fill: colors.black, text: (d) => d.label_1, textAnchor: "end" }), Plot.text( legend.filter((d) => d.line === true), { x: "x2", y: "y", fill: colors.black, text: (d) => d.label_2, textAnchor: "start" } ) ] }); }33:T9c5,adae_plot = { const this_data = data.adae.sort((a, b) => d3.ascending(a.AELLT, b.AELLT)); const start = "ASTDY"; const end = "AENDY"; const one_day = 1000 * 60 * 60 * 24; const trt_start = data.trt_start; const trt_end = data.trt_end; const date_min = data.start; const date_max = data.end; const x_values = produceBreaks(date_min, date_max); const y_values = this_data.map((d, i) => `${d.AELLT}_${i}`); const plot = Plot.plot({ width: width, marginLeft: 320, marginBottom: 40, marginTop: 0, className: "ae", x: x_axis(date_min, date_max, x_values), y: { label: null, domain: y_values, tickFormat: (d, i) => { return d.split("_")[0]; } }, color: { legend: true, domain: ["SEVERE", "MODERATE", "MILD"], range: [ colors.ae_severity.severe, colors.ae_severity.moderate, colors.ae_severity.mild ] }, grid: true, marks: [ Plot.arrow(this_data, { x1: (d) => +d[start], x2: (d) => (d[end] === "NA" ? date_max : +d[end]), y1: (d, i) => `${d.AELLT}_${i}`, y2: (d, i) => `${d.AELLT}_${i}`, strokeWidth: 4, stroke: "AESEV", opacity: (d) => (d[end] === "NA" ? 0.7 : 0), headLength: 3 }), Plot.arrow(this_data, { x1: (d) => +d[start], x2: (d) => (d[end] === "NA" ? date_max : +d[end]), y1: (d, i) => `${d.AELLT}_${i}`, y2: (d, i) => `${d.AELLT}_${i}`, strokeWidth: 4, stroke: "AESEV", opacity: (d) => (d[end] === "NA" ? 0 : 0.7), headLength: 0 }), Plot.dot(this_data, { x: (d) => +d[start], y: (d, i) => `${d.AELLT}_${i}`, r: 4, opacity: (d) => (d[start] < date_min ? 0 : 0.7), strokeWidth: 2, fill: "white", stroke: "AESEV", title: (d) => `Week ${Math.round(d[start] / 7)} \n${d.AELLT} \n(${d.AESEV})` // \n makes a new line }), Plot.dot(this_data, { x: (d) => +d[end], y: (d, i) => `${d.AELLT}_${i}`, r: 3, fill: "AESEV", stroke: "none" }), Plot.dot(this_data, { x: (d) => +d[end], y: (d, i) => `${d.AELLT}_${i}`, r: 2, dy: -8, fill: colors.black, stroke: "none", opacity: (d) => (d.AESER === "Y" ? 1 : 0) }), Plot.ruleX([0], { stroke: colors.black }) ] }); return plot; }34:Ta80,legend_2 = { const legend = [ { x1: -20, x2: -19, y: 0, label_1: "Unknown start ", label_2: "", arrow: false, dot: false, dashed: true }, { x1: -10, x2: -8, y: 0, label_1: "Start date before window ", label_2: " End date", arrow: false, dot: false, dashed: false }, { x1: 0, x2: 2, y: 0, label_1: "Start date ", label_2: " End date", arrow: false, dot: true, dashed: false }, { x1: 10, x2: 12, y: 0, label_1: "Start date ", label_2: " Unknown end date", arrow: true, dot: true, dashed: false } ]; return Plot.plot({ width: 800, marginLeft: 45, marginRight: 120, height: 20, marginBottom: 0, marginTop: 0, className: "ae", x: { label: null, domain: [d3.min(legend, (d) => d.x1) - 2, d3.max(legend, (d) => d.x1) + 2] }, y: { label: "", ticks: 0 }, grid: false, marks: [ Plot.link( legend.filter((d) => d.arrow === false && d.dashed !== true), { x1: "x1", x2: "x2", y1: "y", y2: "y", strokeWidth: 4, stroke: colors.black, opacity: 0.7 } ), Plot.link( legend.filter((d) => d.dashed === true), { x1: "x1", x2: "x2", y1: "y", y2: "y", strokeWidth: 4, stroke: colors.black, opacity: 0.7, strokeDasharray: 4 } ), Plot.arrow( legend.filter((d) => d.arrow === true), { x1: "x1", x2: "x2", y1: "y", y2: "y", strokeWidth: 4, stroke: colors.black, opacity: 0.7, headLength: 3 } ), Plot.dot( legend.filter((d) => d.dot === true), { x: "x1", y: "y", r: 4, strokeWidth: 2, fill: "white", stroke: colors.black } ), Plot.dot( legend.filter((d) => d.arrow === false && d.dashed !== true), { x: "x2", y: "y", r: 3, fill: colors.black, stroke: "none" } ), Plot.text(legend, { x: "x1", y: "y", fill: colors.black, text: (d) => d.label_1, textAnchor: "end" }), Plot.text(legend, { x: "x2", y: "y", fill: colors.black, text: (d) => d.label_2, textAnchor: "start" }) ] }); }35:Tb5d,adcm_plot = { const this_adcm = data.adcm.sort((a, b) => d3.ascending(a.AELLT, b.AELLT)); const start = "ASTDY"; const end = "AENDY"; const one_day = 1000 * 60 * 60 * 24; const unique_meds = d3.groups( this_adcm, (g) => `${g.CMTRT}_${g.CMSTDTC}_${g.AENDT}` ); const this_data = []; for (var n in unique_meds) { this_data.push({ CMTRT: unique_meds[n][1][0].CMTRT, CMSTDTC: parseDate(unique_meds[n][1][0].CMSTDTC), CMENDTC: parseDate(unique_meds[n][1][0].CMENDTC), AENDT: parseDate(unique_meds[n][1][0].AENDT), TRTSDT: parseDate(unique_meds[n][1][0].TRTSDT), TRTEDT: parseDate(unique_meds[n][1][0].TRTEDT), ASTDY: +unique_meds[n][1][0].ASTDY, AENDY: +unique_meds[n][1][0].AENDY, data: "adcm" }); } const trt_start = data.trt_start; const trt_end = data.trt_end; const date_min = data.start; const date_max = data.end; const x_values = produceBreaks(date_min, date_max); const y_values = this_data.map((d, i) => d.CMTRT); const plot = Plot.plot({ width: width, marginLeft: 320, marginTop: 0, marginBottom: 40, x: x_axis(date_min, date_max, x_values), y: { label: null, domain: y_values }, grid: true, marks: [ Plot.link( this_data.filter((d) => isNaN(d[start])), { x1: x_values[0], x2: trt_start, y1: "CMTRT", y2: "CMTRT", strokeWidth: 4, stroke: colors.grey, opacity: 0.7, strokeDasharray: 4 } ), Plot.arrow(this_data, { x1: (d) => (isNaN(d[start]) ? trt_start : d[start]), x2: (d) => (isNaN(d[end]) ? date_max : d[end]), y1: "CMTRT", y2: "CMTRT", strokeWidth: 4, stroke: colors.grey, opacity: (d) => (isNaN(d[end]) ? 0.7 : 0), headLength: 3 }), Plot.arrow(this_data, { x1: (d) => (isNaN(d[start]) ? trt_start : d[start]), x2: (d) => (isNaN(d[end]) ? date_max : d[end]), y1: "CMTRT", y2: "CMTRT", strokeWidth: 4, stroke: colors.grey, opacity: (d) => (isNaN(d[end]) ? 0 : 0.7), headLength: 0 }), Plot.dot( this_data.filter((d) => d.CMSTDTC > d.TRTSDT), { x: (d) => d[start], y: "CMTRT", r: 4, strokeWidth: 3, fill: "white", stroke: colors.grey, title: (d) => `Week ${Math.round(d[start] / 7)} \n${d.CMTRT}` // \n makes a new line } ), Plot.dot( this_data.filter((d) => +d[end] <= date_max), { x: (d) => +d[end], y: "CMTRT", r: 3, fill: colors.grey, stroke: "none" } ), Plot.ruleX([0], { stroke: colors.black }) ] }); return date_max > 0 ? plot : "No data available"; }36:T47d,metadata_ex = [ { variable: "STUDYID", description: "Study Identifier " }, { variable: "DOMAIN", description: "Domain Abbreviation " }, { variable: "USUBJID", description: "Unique Subject Identifier " }, { variable: "EXSEQ", description: "Sequence Number " }, { variable: "EXTRT", description: "Name of Treatment " }, { variable: "EXDOSE", description: "Dose " }, { variable: "EXDOSU", description: "Dose Units " }, { variable: "EXDOSFRM", description: "Dose Form " }, { variable: "EXDOSFRQ", description: "Dosing Frequency per Interval " }, { variable: "EXROUTE", description: "Route of Administration " }, { variable: "VISITNUM", description: "Visit Number " }, { variable: "VISIT", description: "Visit Name " }, { variable: "VISITDY", description: "Planned Study Day of Visit " }, { variable: "EPOCH", description: "Epoch " }, { variable: "EXSTDTC", description: "Start Date/Time of Treatment " }, { variable: "EXENDTC", description: "End Date/Time of Treatment " }, { variable: "EXSTDY", description: "Study Day of Start of Treatment " }, { variable: "EXENDY", description: "Study Day of End of Treatment" } ]37:Tb43,metadata_adcm = [ { variable: "STUDYID", description: "Study Identifier" }, { variable: "SITEID", description: "Study Site Identifier" }, { variable: "USUBJID", description: "Unique Subject Identifier" }, { variable: "TRTA", description: "Actual Treatment" }, { variable: "TRTAN", description: "Actual Treatment (N)" }, { variable: "AGE", description: "Age: activate to sort column ascending" }, { variable: "AGEGR1", description: "Pooled Age Group 1" }, { variable: "AGEGR1N", description: "Pooled Age Group 1 (N)" }, { variable: "RACE", description: "Race" }, { variable: "RACEN", description: "Race (N)" }, { variable: "SEX", description: "Sex" }, { variable: "SAFFL", description: "Safety Population Flag" }, { variable: "TRTSDT", description: "Date of First Exposure to Treatment" }, { variable: "TRTEDT", description: "Date of Last Exposure to Treatment" }, { variable: "ASTDT", description: "Analysis Start Date" }, { variable: "ASTDTF", description: "Analysis Start Date Imputation Flag" }, { variable: "ASTDY", description: "Analysis Start Relative Day" }, { variable: "AENDT", description: "Analysis End Date" }, { variable: "AENDTF", description: "Analysis End Date Imputation Flag" }, { variable: "AENDY", description: "Analysis End Relative Day" }, { variable: "AENRF", description: "Analysis End Relative to Ref Period" }, { variable: "ADURN", description: "AE Duration (N)" }, { variable: "CMSTDTC", description: "Start Date/Time of Medication" }, { variable: "CMENDTC", description: "End Date/Time of Medication" }, { variable: "CMSEQ", description: "Sequence Number" }, { variable: "CMSPID", description: "Sponsor-Defined Identifier" }, { variable: "CMTRT", description: "Reported Name of Drug, Med, or Therapy" }, { variable: "CMDECOD", description: "Standarized Medication Name" }, { variable: "CMINDC", description: "Indication" }, { variable: "CMCLAS", description: "Medication Class" }, { variable: "CMDOSE", description: "Dose per Administration" }, { variable: "CMDOSU", description: "Dose Units" }, { variable: "CMDOSFRQ", description: "Dosing Frequency per Interval" }, { variable: "CMROUTE", description: "Route of Administration" }, { variable: "PREFL", description: "Pre-treatment Flag" }, { variable: "ONTRTFL", description: "On-treatment Flag" }, { variable: "AOCCBFL", description: "1st Prior Ocurrence Within Subject Flg" }, { variable: "ATC1BFL", description: "1st Prior Ocurrence of ATC Level 1 Flg" }, { variable: "AOCCBPFL", description: "1st Prior Ocurrence of Pref Term Flg" }, { variable: "AOCCOFL", description: "1st On-Trt Ocurrence Within Subject Flg" }, { variable: "ATC1OFL", description: "1st On-Trt Ocurrence of ATC Level 1 Flg" }, { variable: "AOCCOPFL", description: "1st On-Trt Ocurrence of Pref Term Flg" } ]38:Tce7,metadata_adae = [ { variable: "STUDYID", description: "Study Identifier" }, { variable: "SITEID", description: "Study Site Identifier" }, { variable: "USUBJID", description: "Unique Subject Identifier" }, { variable: "TRTA", description: "Actual Treatment" }, { variable: "TRTAN", description: "Actual Treatment (N)" }, { variable: "AGE", description: "Age: activate to sort column ascending" }, { variable: "AGEGR1", description: "Pooled Age Group 1" }, { variable: "AGEGR1N", description: "Pooled Age Group 1 (N)" }, { variable: "RACE", description: "Race" }, { variable: "RACEN", description: "Race (N)" }, { variable: "SEX", description: "Sex" }, { variable: "SAFFL", description: "Safety Population Flag" }, { variable: "TRTSDT", description: "Date of First Exposure to Treatment" }, { variable: "TRTEDT", description: "Date of Last Exposure to Treatment" }, { variable: "ASTDT", description: "Analysis Start Date" }, { variable: "ASTDTF", description: "Analysis Start Date Imputation Flag" }, { variable: "ASTDY", description: "Analysis Start Relative Day" }, { variable: "AENDT", description: "Analysis End Date" }, { variable: "AENDY", description: "Analysis End Relative Day" }, { variable: "ADURN", description: "AE Duration (N)" }, { variable: "ADURU", description: "AE Duration Units" }, { variable: "AETERM", description: "Reported Term for the Adverse Event" }, { variable: "AELLT", description: "Lowest Level Term" }, { variable: "AELLTCD", description: "Lowest Level Term Code" }, { variable: "AEDECOD", description: "Dictionary-Derived Term" }, { variable: "AEPTCD", description: "Preferred Term Code" }, { variable: "AEHLT", description: "High Level Term" }, { variable: "AEHLTCD", description: "High Level Term Code" }, { variable: "AEHLGT", description: "High Level Group Term" }, { variable: "AEHLGTCD", description: "High Level Group Term Code" }, { variable: "AEBODSYS", description: "Body System or Organ Class" }, { variable: "AESOC", description: "Primary System Organ Class" }, { variable: "AESOCCD", description: "Primary System Organ Class Code" }, { variable: "AESEV", description: "Severity/Intensity" }, { variable: "AESER", description: "Serious Event" }, { variable: "AESCAN", description: "Involves Cancer" }, { variable: "AESCONG", description: "Congenital Anomaly or Birth Defect" }, { variable: "AESDISAB", description: "Persist or Signif Disability/Incapacity" }, { variable: "AESDTH", description: "Results in Death" }, { variable: "AESHOSP", description: "Requires or Prolongs Hospitalization" }, { variable: "AESLIFE", description: "Is Life Threatening" }, { variable: "AESOD", description: "Occurred with Overdose" }, { variable: "AEREL", description: "Causality" }, { variable: "AEACN", description: "Action Taken with Study Treatment" }, { variable: "AEOUT", description: "Outcome of Adverse Event" }, { variable: "AESEQ", description: "Sequence Number" }, { variable: "TRTEMFL", description: "Treatment Emergent Analysis Flag" }, { variable: "AOCCFL", description: "1st Occurrence of Any AE Flag" }, { variable: "AOCCSFL", description: "1st Occurrence of SOC Flag" }, { variable: "AOCCPFL", description: "1st Occurrence of Preferred Term Flag" } ]39:Tbb8,metadata_adlbc = [ { variable: "STUDYID", description: "Study Identifier" }, { variable: "SUBJID", description: "Subject Identifier for the Study" }, { variable: "USUBJID", description: "Unique Subject Identifier" }, { variable: "TRTP", description: "Planned Treatment" }, { variable: "TRTPN", description: "Planned Treatment (N)" }, { variable: "TRTA", description: "Actual Treatment" }, { variable: "TRTAN", description: "Actual Treatment (N)" }, { variable: "TRTSDT", description: "Date of First Exposure to Treatment" }, { variable: "TRTEDT", description: "Date of Last Exposure to Treatment" }, { variable: "AGE", description: "Age" }, { variable: "AGEGR1", description: "Pooled Age Group" }, { variable: "AGEGR1N", description: "Pooled Age Group 1 (N)" }, { variable: "RACE", description: "Race " }, { variable: "RACEN", description: "Race (N)" }, { variable: "SEX", description: "Sex" }, { variable: "COMP24FL", description: "Completers of Week 24 Population Flag" }, { variable: "DSRAEFL", description: "Discontinued due to AE?" }, { variable: "SAFFL", description: "Safety Population Flag" }, { variable: "AVISIT", description: "Analysis Visit" }, { variable: "AVISITN", description: "Analysis Visit (N)" }, { variable: "ADY", description: "Analysis Relative Day" }, { variable: "ADT", description: "Analysis Date" }, { variable: "VISIT", description: "Visit Name" }, { variable: "VISITNUM", description: "Visit Number" }, { variable: "PARAM", description: "Parameter" }, { variable: "PARAMCD", description: "Parameter Code" }, { variable: "PARAMN", description: "Parameter (N)" }, { variable: "PARCAT 1", description: "Parameter Category 1" }, { variable: "AVAL", description: "Analysis Value" }, { variable: "BASE", description: "Baseline Value" }, { variable: "CHG", description: "Change from Baseline" }, { variable: "A1LO", description: "Analysis Range 1 Lower Limit" }, { variable: "A1HI", description: "Analysis Range 1 Upper Limit" }, { variable: "R2A1LO", description: "Ratio to Analysis Range 1 Lower Limit" }, { variable: "R2A1HI", description: "Ratio to Analysis Range 1 Upper Limit" }, { variable: "BR2A1LO", description: "Base Ratio to Analysis Range 1 Lower Lim" }, { variable: "BR2A1HI", description: "Base Ratio to Analysis Range 1 Upper Lim" }, { variable: "ANL01FL", description: "Analysis Record Flag 1" }, { variable: "ALBTRVAL", description: "Amount Threshold Range" }, { variable: "ANRIND", description: "Analysis Reference Range" }, { variable: "BNRIND", description: "Baseline Reference Range" }, { variable: "ABLFL", description: "Baseline Record Flag" }, { variable: "AENTMTFL", description: "Last value in treatment visit" }, { variable: "LBSEQ", description: "Sequence Number" }, { variable: "LBNRIND", description: "Reference Range Indicator" }, { variable: "LBSTRESN", description: "Numeric Result/Finding in Standard Units" } ]3a:Tbcc,metadata_adlbh = [ { variable: "STUDYID", description: "Study Identifier" }, { variable: "SUBJID", description: "Subject Identifier for the Study" }, { variable: "USUBJID", description: "Unique Subject Identifier" }, { variable: "TRTP", description: "Planned Treatment" }, { variable: "TRTPN", description: "Planned Treatment (N)" }, { variable: "TRTA", description: "Actual Treatment" }, { variable: "TRTAN", description: "Actual Treatment (N)" }, { variable: "TRTSDT", description: "Date of First Exposure to Treatment" }, { variable: "TRTEDT", description: "Date of Last Exposure to Treatment" }, { variable: "AGE", description: "Age" }, { variable: "AGEGR1", description: "Pooled Age Group 1" }, { variable: "AGEGR1N", description: "Pooled Age Group 1 (N)" }, { variable: "RACE", description: "Race" }, { variable: "RACEN", description: "Race (N)" }, { variable: "SEX", description: "Sex" }, { variable: "COMP24FL", description: "Completers of Week 24 Population Flag" }, { variable: "DSRAEFL", description: "Discontinued due to AE?" }, { variable: "SAFFL", description: "Safety Population Flag" }, { variable: "AVISIT", description: "Analysis Visit" }, { variable: "AVISITN", description: "Analysis Visit (N)" }, { variable: "ADY", description: "Analysis Relative Day" }, { variable: "ADT", description: "Analysis Date" }, { variable: "VISIT", description: "Visit Name" }, { variable: "VISITNUM", description: "Visit Number" }, { variable: "PARAM", description: "Parameter" }, { variable: "PARAMCD", description: "Parameter Code" }, { variable: "PARAMN", description: "Parameter (N)" }, { variable: "PARCAT1", description: "Parameter Category 1" }, { variable: "AVAL", description: "Analysis Value" }, { variable: "BASE", description: "Baseline Value" }, { variable: "CHG", description: "Change from Baseline" }, { variable: "A1LO", description: "Analysis Range 1 Lower Limit" }, { variable: "A1HI", description: "Analysis Range 1 Upper Limit" }, { variable: "R2A1LO", description: "Ratio to Analysis Range 1 Lower Limit" }, { variable: "R2A1HI", description: "Ratio to Analysis Range 1 Upper Limit" }, { variable: "BR2A1LO", description: "Base Ratio to Analysis Range 1 Lower Lim" }, { variable: "BR2A1HI", description: "Base Ratio to Analysis Range 1 Upper Lim" }, { variable: "ANL01FL", description: "Analysis Record Flag 1" }, { variable: "ALBTRVAL", description: "Amount Threshold Range" }, { variable: "ANRIND", description: "Analysis Reference Range Indicator" }, { variable: "BNRIND", description: "Baseline Reference Range Indicator" }, { variable: "ABLFL", description: "Baseline Record Flag" }, { variable: "AENTMTFL", description: "Last value in treatment visit" }, { variable: "LBSEQ", description: "Sequence Number" }, { variable: "LBNRIND", description: "Reference Range Indicator" }, { variable: "LBSTRESN", description: "Numeric Result/Finding in Standard Units" } ]3b:Tacd,metadata_adlbhy = [ { variable: "STUDYID", description: "Study Identifier" }, { variable: "SUBJID", description: "Subject Identifier for the Study" }, { variable: "USUBJID", description: "Unique Subject Identifier" }, { variable: "TRTP", description: "Planned Treatment" }, { variable: "TRTPN", description: "Planned Treatment (N)" }, { variable: "TRTA", description: "Actual Treatment" }, { variable: "TRTAN", description: "Actual Treatment (N)" }, { variable: "TRTSDT", description: "Date of First Exposure to Treatment" }, { variable: "TRTEDT", description: "Date of Last Exposure to Treatment" }, { variable: "AGE", description: "Age" }, { variable: "AGEGR1", description: "Pooled Age Group 1" }, { variable: "AGEGR1N", description: "Pooled Age Group 1 (N)" }, { variable: "RACE", description: "Race" }, { variable: "RACEN", description: "Race (N)" }, { variable: "SEX", description: "Sex" }, { variable: "COMP24FL", description: "Completers of Week 24 Population Flag" }, { variable: "DSRAEFL", description: "Discontinued due to AE?" }, { variable: "SAFFL", description: "Safety Population Flag" }, { variable: "AVISIT", description: "Analysis Visit" }, { variable: "AVISITN", description: "Analysis Visit (N)" }, { variable: "ADY", description: "Analysis Relative Day" }, { variable: "ADT", description: "Analysis Date" }, { variable: "VISIT", description: "Visit Name" }, { variable: "VISITNUM", description: "Visit Number" }, { variable: "PARAMTYP", description: "Parameter Type" }, { variable: "PARAM", description: "Parameter" }, { variable: "PARAMCD", description: "Parameter Code" }, { variable: "PARAMN", description: "Parameter (N)" }, { variable: "PARCAT1", description: "Parameter Category 1" }, { variable: "AVAL", description: "Analysis Value" }, { variable: "BASE", description: "Baseline Value" }, { variable: "A1LO", description: "Analysis Range 1 Lower Limit" }, { variable: "A1HI", description: "Analysis Range 1 Upper Limit" }, { variable: "R2A1LO", description: "Ratio to Analysis Range 1 Lower Limit" }, { variable: "R2A1HI", description: "Ratio to Analysis Range 1 Upper Limit" }, { variable: "BR2A1LO", description: "Base Ratio to Analysis Range 1 Lower Lim" }, { variable: "BR2A1HI", description: "Base Ratio to Analysis Range 1 Upper Lim" }, { variable: "ABLFL", description: "Baseline Record Flag" }, { variable: "SHIFT1", description: "Shift 1" }, { variable: "SHIFT1N", description: "Shift 1 (N)" }, { variable: "CRIT1", description: "Analysis Criterion 1" }, { variable: "CRIT1FL", description: "Criterion 1 Evaluation Result Flag" }, { variable: "CRIT1FN", description: "Criterion 1 Evaluation Result Flag (N)" } ]3c:T782,function createPlot_adlbc_h(param, dataset, index) { const this_data = dataset .sort((a, b) => d3.ascending(a.PARAM, b.PARAM)) .sort((a, b) => +a.ADY - +b.ADY) .filter((d) => d.PARAM === param); const x = "ADY"; const y = "AVAL"; const date_min = d3.min(this_data, (d) => +d[x]); const date_max = d3.max(this_data, (d) => +d[x]); const x_values = produceBreaks(date_min, date_max); const plot = Plot.plot({ width: width, height: 200, marginLeft: marginLeft, marginRight: 50, marginBottom: 40, marginTop: 30, className: "adlbc", x: x_axis(date_min, date_max, x_values), y: { label: this_data[1].PARAM }, color: { legend: index === 0 ? true : false, label: "Reference Range Indicator", domain: ["ABNORMAL", "HIGH", "NORMAL", "LOW"], range: [ colors.ae_severity.severe, colors.indicators_high, colors.indicators, colors.indicators_low ] }, grid: true, marks: [ Plot.areaY(this_data, { x: `${x}`, y1: (d) => +d[y], y2: 0, fill: colors.indicators, // curve: "step-after", opacity: 0.25 }), Plot.line(this_data, { x: `${x}`, y: (d) => +d[y], strokeWidth: 3, stroke: colors.indicators // curve: "step-after" }), Plot.ruleX([0], { stroke: colors.black }), Plot.ruleY([0], { stroke: colors.black, opacity: d3.max(this_data, (d) => +d[y]) === 0 ? 0 : 1 }), Plot.dot( this_data.filter((d) => d.LBNRIND !== "NA" || d.LBNRIND !== ""), { x: `${x}`, y: (d) => +d[y], r: 4, fill: "white", strokeWidth: (d) => (d.LBNRIND === "NORMAL" ? 2 : 4), stroke: "LBNRIND" } ) ] }); return this_data.length > 0 ? plot : "No data available"; }3d:T858,function createPlot_adlbc_h_small(param, dataset, index) { const this_data = dataset .sort((a, b) => d3.ascending(a.PARAM, b.PARAM)) .sort((a, b) => +a.ADY - +b.ADY) .filter((d) => d.PARAM === param); const x = "ADY"; const y = "AVAL"; const date_min = d3.min(this_data, (d) => +d[x]); const date_max = d3.max(this_data, (d) => +d[x]); const x_values = produceBreaks(date_min, date_max); const plot = Plot.plot({ width: width > 500 ? width / 4 : width, height: 150, marginLeft: 30, marginRight: 50, marginBottom: 40, marginTop: 30, className: "adlbc", x: x_axis(date_min, date_max, x_values), y: { label: null }, color: { // legend: index === 0 ? true : false, label: "Reference Range Indicator", domain: ["ABNORMAL", "HIGH", "NORMAL", "LOW"], range: [ colors.ae_severity.severe, colors.indicators_high, colors.indicators, colors.indicators_low ] }, grid: true, marks: [ Plot.areaY(this_data, { x: `${x}`, y1: (d) => +d[y], y2: 0, fill: colors.light_grey, // curve: "step-after", opacity: 0.5 }), Plot.line(this_data, { x: `${x}`, y: (d) => +d[y], strokeWidth: 2, stroke: colors.indicators // curve: "step-after" }), Plot.ruleX([0], { stroke: colors.black }), Plot.ruleY([0], { stroke: colors.black, opacity: d3.max(this_data, (d) => +d[y]) === 0 ? 0 : 1 }), Plot.dot( this_data.filter((d) => d.LBNRIND !== "NA" || d.LBNRIND !== ""), { x: `${x}`, y: (d) => +d[y], r: (d) => (d.LBNRIND === "NORMAL" ? 2 : 4), fill: "white", strokeWidth: (d) => (d.LBNRIND === "NORMAL" ? 2 : 4), stroke: "LBNRIND", title: (d) => `Week ${Math.round(d[x] / 7)} \n Analysis Value: ${d[y]} \n (${ d.LBNRIND })` // \n makes a new line } ) ] }); return this_data.length > 0 ? plot : "No data available"; }3e:T544,3f:[{"id":"bad9d06e73074a87e151ff30560d2c77641da04e472a3b13fd6675472219b01800daee2dc25d26609228bf3290df2251f301a214ca64d29a42e81a55d46c0520","href":"https://static.observableusercontent.com/files/bad9d06e73074a87e151ff30560d2c77641da04e472a3b13fd6675472219b01800daee2dc25d26609228bf3290df2251f301a214ca64d29a42e81a55d46c0520","name":"ex-all.csv","type":"text/csv","lastModified":1656324794453.966,"size":69590},{"id":"a4d5bc0b521f722f64d1492c92f28e61ae414bf93edb0ba6ea8ae2b31c164078d65850bee70056a185caacc97a6627fb08aab78ffd92a6b7cd0ab3967d2beca9","href":"https://static.observableusercontent.com/files/a4d5bc0b521f722f64d1492c92f28e61ae414bf93edb0ba6ea8ae2b31c164078d65850bee70056a185caacc97a6627fb08aab78ffd92a6b7cd0ab3967d2beca9","name":"adlbc-all.csv","type":"text/csv","lastModified":1656498999950.589,"size":23567302},{"id":"a4204f17e18717173bc5446fd326c17ee2143fdb7a515a70ae2ab293eb8dd51982e2ef0de7a89e1721e99486bbcb8c22d2a8917b4c94f0339ab6138c72e0a3ba","href":"https://static.observableusercontent.com/files/a4204f17e18717173bc5446fd326c17ee2143fdb7a515a70ae2ab293eb8dd51982e2ef0de7a89e1721e99486bbcb8c22d2a8917b4c94f0339ab6138c72e0a3ba","name":"adcm-all.csv","type":"text/csv","lastModified":1656073671679.933,"size":1680855},{"id":"95ac6c7d46799935fd65d514878c8bcbf3b40596a67860d869b77b39daedb0823513d2f880b920a65a56066e38ce8b97f0328ae48470f760d75e537d66129ec9","href":"https://static.observableusercontent.com/files/95ac6c7d46799935fd65d514878c8bcbf3b40596a67860d869b77b39daedb0823513d2f880b920a65a56066e38ce8b97f0328ae48470f760d75e537d66129ec9","name":"adlbhy-all.csv","type":"text/csv","lastModified":1656583277294.624,"size":2704104},{"id":"1e2a520ee84de0037b7c7768e43f1223c68efdc7e22219589ff9c7a20a75a9e149c0b1e3ca9546ed4eb77dc9f2f1e824828d891d3709cab3da8c12fb662a8fa0","href":"https://static.observableusercontent.com/files/1e2a520ee84de0037b7c7768e43f1223c68efdc7e22219589ff9c7a20a75a9e149c0b1e3ca9546ed4eb77dc9f2f1e824828d891d3709cab3da8c12fb662a8fa0","name":"adlbh-all.csv","type":"text/csv","lastModified":1656581216621.952,"size":16191071},{"id":"b24e05c546e5bf231f17135fa1e22d0eef3924914f52239faba5b5357f9fc0d48aa1f545ef227e400daf16bee5de3959890c934dac098204e285ee8a649941f5","href":"https://static.observableusercontent.com/files/b24e05c546e5bf231f17135fa1e22d0eef3924914f52239faba5b5357f9fc0d48aa1f545ef227e400daf16bee5de3959890c934dac098204e285ee8a649941f5","name":"adae-all.csv","type":"text/csv","lastModified":1655995859259.729,"size":428354}] 2f:{"title":"Patient Profiles, Wonderful Wednesdays June Challenge","cells":[{"id":0,"value":"# Patient Profiles, Wonderful Wednesdays June Challenge","pinned":false,"hidden":false,"mode":"md"},{"id":30,"value":"viewof select_USUBJID = Inputs.select(subject_ids, {\n label: \"Select a subject\",\n value: \"01-701-1146\"\n})","pinned":false,"hidden":false,"mode":"ojs"},{"id":47,"value":"

Demographic information

\n\n

\n Sex: ${data.adae[0].SEX} | \n Age: ${data.adae[0].AGE} | \n Race: ${data.adae[0].RACE}\n

","pinned":false,"hidden":false,"mode":"html"},{"id":91,"value":"

\nTreatment: ${data.ex[0].EXTRT}\n

","pinned":false,"hidden":false,"mode":"html"},{"id":1009,"value":"

1. Patient Drug Exposure by Dose Units

","pinned":false,"hidden":false,"mode":"html"},{"id":793,"value":"$31","pinned":false,"hidden":false,"mode":"ojs"},{"id":309,"value":"

2. Adverse Events & Concomitant Medications

","pinned":false,"hidden":false,"mode":"html"},{"id":658,"value":"

Adverse Events Records by ${\n metadata_adae.filter((d) => d.variable === \"AELLT\")[0].description\n }

","pinned":false,"hidden":false,"mode":"html"},{"id":569,"value":"$32","pinned":false,"hidden":false,"mode":"ojs"},{"id":50,"value":"$33","pinned":false,"hidden":false,"mode":"ojs"},{"id":567,"value":"

Concomitant Medications Records by ${\n metadata_adcm.filter((d) => d.variable === \"CMTRT\")[0].description\n }

","pinned":false,"hidden":false,"mode":"html"},{"id":1583,"value":"$34","pinned":false,"hidden":false,"mode":"ojs"},{"id":468,"value":"$35","pinned":false,"hidden":false,"mode":"ojs"},{"id":1465,"value":"

3. Patient chemistry lab measurements by parameter and reference range indicator

","pinned":false,"hidden":false,"mode":"html"},{"id":1981,"value":"Plot.legend({\n color: {\n domain: [\"ABNORMAL\", \"HIGH\", \"NORMAL\", \"LOW\"],\n range: [\n colors.ae_severity.severe,\n colors.indicators_high,\n colors.indicators,\n colors.indicators_low\n ]\n },\n label: \"Reference Range Indicator\"\n})","pinned":false,"hidden":false,"mode":"ojs"},{"id":1214,"value":"{\n const param = d3.groupSort(\n data.adlbc,\n (g) => g.PARAM,\n (d) => d.PARAM\n );\n\n const divs = [];\n const plots = param.forEach((d, i) =>\n divs.push({ title: d, plot: createPlot_adlbc_h_small(d, data.adlbc, i) })\n );\n\n return wrap_small(divs);\n}","pinned":false,"hidden":false,"mode":"ojs"},{"id":1775,"value":"

4. Patient hematology lab measurements by parameter and reference range indicator

","pinned":false,"hidden":false,"mode":"html"},{"id":2001,"value":"Plot.legend({\n color: {\n domain: [\"ABNORMAL\", \"HIGH\", \"NORMAL\", \"LOW\"],\n range: [\n colors.ae_severity.severe,\n colors.indicators_high,\n colors.indicators,\n colors.indicators_low\n ]\n },\n label: \"Reference Range Indicator\"\n})","pinned":false,"hidden":false,"mode":"ojs"},{"id":1786,"value":"{\n const param = d3.groupSort(\n data.adlbh,\n (g) => g.PARAM,\n (d) => d.PARAM\n );\n\n const divs = [];\n // const plots = param.forEach((d, i) =>\n // divs.push(createPlot_adlbc_h(d, data.adlbh, i))\n // );\n\n // return param.length === 0 ? \"No measurements available\" : wrap(divs);\n\n const plots = param.forEach((d, i) =>\n divs.push({ title: d, plot: createPlot_adlbc_h_small(d, data.adlbh, i) })\n );\n\n return wrap_small(divs);\n}","pinned":false,"hidden":false,"mode":"ojs"},{"id":1814,"value":"","pinned":false,"hidden":false,"mode":"html"},{"id":438,"value":"---\n### Subject tables","pinned":false,"hidden":false,"mode":"md"},{"id":769,"value":"##### ex - Patient drug exposure","pinned":false,"hidden":false,"mode":"md"},{"id":771,"value":"viewof search_ex = Inputs.search(data.ex)","pinned":false,"hidden":false,"mode":"ojs"},{"id":775,"value":"viewof table_USUBJID_ex = Inputs.table(search_ex)","pinned":false,"hidden":false,"mode":"ojs"},{"id":676,"value":"##### adae - patient adverse event records","pinned":false,"hidden":false,"mode":"md"},{"id":195,"value":"viewof search_adae = Inputs.search(data.adae)","pinned":false,"hidden":false,"mode":"ojs"},{"id":69,"value":"viewof table_USUBJID_adae = Inputs.table(search_adae)","pinned":false,"hidden":false,"mode":"ojs"},{"id":680,"value":"##### adcm - concomitant medications records","pinned":false,"hidden":false,"mode":"md"},{"id":440,"value":"viewof search_adcm = Inputs.search(data.adcm)","pinned":false,"hidden":false,"mode":"ojs"},{"id":445,"value":"viewof table_USUBJID_adcm = Inputs.table(search_adcm)","pinned":false,"hidden":false,"mode":"ojs"},{"id":1220,"value":"##### adlbc - Patient chemistry lab measurements","pinned":false,"hidden":false,"mode":"md"},{"id":1225,"value":"viewof search_adlbc = Inputs.search(data.adlbc)","pinned":false,"hidden":false,"mode":"ojs"},{"id":1228,"value":"viewof table_USUBJID_adlbc = Inputs.table(search_adlbc)","pinned":false,"hidden":false,"mode":"ojs"},{"id":1866,"value":"##### adlbh - Patient hematology lab measurements","pinned":false,"hidden":false,"mode":"md"},{"id":1871,"value":"viewof search_adlbh = Inputs.search(data.adlbh)","pinned":false,"hidden":false,"mode":"ojs"},{"id":1874,"value":"viewof table_USUBJID_adlbh = Inputs.table(search_adlbh)","pinned":false,"hidden":false,"mode":"ojs"},{"id":1877,"value":"##### adlbhy - Patient Hy rules lab measurements","pinned":false,"hidden":false,"mode":"md"},{"id":1882,"value":"viewof search_adlbhy = Inputs.search(data.adlbhy)","pinned":false,"hidden":false,"mode":"ojs"},{"id":1885,"value":"viewof table_USUBJID_adlbhy = Inputs.table(search_adlbhy)","pinned":false,"hidden":false,"mode":"ojs"},{"id":375,"value":"----\n\n## Data - Wonderful Wednesday's June 2022 Challenge\n\n- ex - patient drug exposure\n- adcm - patient con medication records\n- adae - patient adverse event records\n- adlbc - patient chemistry lab measurements\n- adlbh - patient hematology lab measurements\n- adlbhy - patient lab measurements - Hy rules","pinned":false,"hidden":false,"mode":"md"},{"id":1743,"value":"data = {\n return {\n adae: adae.filter((d) => d.USUBJID === select_USUBJID),\n adcm: adcm.filter((d) => d.USUBJID === select_USUBJID),\n ex: ex.filter((d) => d.USUBJID === select_USUBJID),\n adlbc: adlbc.filter((d) => d.USUBJID === select_USUBJID),\n adlbh: adlbh.filter((d) => d.USUBJID === select_USUBJID),\n adlbhy: adlbhy.filter((d) => d.USUBJID === select_USUBJID),\n trt_end: d3.max(\n ex.filter((d) => d.USUBJID === select_USUBJID),\n (d) => +d.EXENDY\n ),\n trt_start: 0,\n start: d3.min(\n adlbc.filter((d) => d.USUBJID === select_USUBJID),\n (d) => +d.ADY\n ),\n end: d3.max(\n adlbc.filter((d) => d.USUBJID === select_USUBJID),\n (d) => +d.ADY\n )\n };\n}","pinned":false,"hidden":false,"mode":"ojs"},{"id":739,"value":"---\n\n### `ex`: patient drug exposure","pinned":false,"hidden":false,"mode":"md"},{"id":746,"value":"ex = FileAttachment(\"ex-all.csv\").csv()","pinned":false,"hidden":false,"mode":"ojs"},{"id":753,"value":"$36","pinned":false,"hidden":false,"mode":"ojs"},{"id":756,"value":"Metadata information:","pinned":false,"hidden":false,"mode":"md"},{"id":760,"value":"viewof search_meta_ex = Inputs.search(metadata_ex)","pinned":false,"hidden":false,"mode":"ojs"},{"id":763,"value":"viewof table_meta_ex = Inputs.table(search_meta_ex)","pinned":false,"hidden":false,"mode":"ojs"},{"id":386,"value":"---\n\n### `adcm`: Patient con medication records","pinned":false,"hidden":false,"mode":"md"},{"id":388,"value":"adcm = FileAttachment(\"adcm-all.csv\").csv()","pinned":false,"hidden":false,"mode":"ojs"},{"id":396,"value":"$37","pinned":false,"hidden":false,"mode":"ojs"},{"id":450,"value":"Metadata information:","pinned":false,"hidden":false,"mode":"md"},{"id":424,"value":"viewof search_meta_adcm = Inputs.search(metadata_adcm)","pinned":false,"hidden":false,"mode":"ojs"},{"id":427,"value":"viewof table_meta_adcm = Inputs.table(search_meta_adcm)","pinned":false,"hidden":false,"mode":"ojs"},{"id":17,"value":"---\n\n### `adae:` Adverse events","pinned":false,"hidden":false,"mode":"md"},{"id":6,"value":"adae = FileAttachment(\"adae-all.csv\").csv()","pinned":false,"hidden":false,"mode":"ojs"},{"id":416,"value":"$38","pinned":false,"hidden":false,"mode":"ojs"},{"id":44,"value":"Metadata information:","pinned":false,"hidden":false,"mode":"md"},{"id":407,"value":"viewof search_meta_adae = Inputs.search(metadata_adae)","pinned":false,"hidden":false,"mode":"ojs"},{"id":410,"value":"viewof table_meta_adae = Inputs.table(search_meta_adae)","pinned":false,"hidden":false,"mode":"ojs"},{"id":1124,"value":"---\n\n### `adlbc:` Patient chemistry lab measurements","pinned":false,"hidden":false,"mode":"md"},{"id":1120,"value":"adlbc = FileAttachment(\"adlbc-all.csv\").csv()","pinned":false,"hidden":false,"mode":"ojs"},{"id":1155,"value":"$39","pinned":false,"hidden":false,"mode":"ojs"},{"id":1158,"value":"Metadata information:","pinned":false,"hidden":false,"mode":"md"},{"id":1162,"value":"viewof search_meta_adlbc = Inputs.search(metadata_adlbc)","pinned":false,"hidden":false,"mode":"ojs"},{"id":1166,"value":"viewof table_meta_adlbc = Inputs.table(search_meta_adlbc)","pinned":false,"hidden":false,"mode":"ojs"},{"id":1769,"value":"param_biochem = d3.groupSort(\n adlbc,\n (g) => g[0].PARAM,\n (d) => d.PARAM.split(ablbc_split)[0]\n)","pinned":false,"hidden":false,"mode":"ojs"},{"id":1733,"value":"---\n\n### `adlbh:` Patient hematology lab measurements","pinned":false,"hidden":false,"mode":"md"},{"id":1737,"value":"adlbh = FileAttachment(\"adlbh-all.csv\").csv()","pinned":false,"hidden":false,"mode":"ojs"},{"id":1746,"value":"$3a","pinned":false,"hidden":false,"mode":"ojs"},{"id":1749,"value":"Metadata information:","pinned":false,"hidden":false,"mode":"md"},{"id":1753,"value":"viewof search_meta_adlbh = Inputs.search(metadata_adlbh)","pinned":false,"hidden":false,"mode":"ojs"},{"id":1758,"value":"viewof table_meta_adlbh = Inputs.table(search_meta_adlbh)","pinned":false,"hidden":false,"mode":"ojs"},{"id":1772,"value":"param_adlbh = d3.groupSort(\n adlbh,\n (g) => g[0].PARAM,\n (d) => d.PARAM.split(ablbc_split)[0]\n)","pinned":false,"hidden":false,"mode":"ojs"},{"id":1821,"value":"---\n\n### `adlbhy:` Patient lab measurements - Hy rule","pinned":false,"hidden":false,"mode":"md"},{"id":1831,"value":"adlbhy = FileAttachment(\"adlbhy-all.csv\").csv()","pinned":false,"hidden":false,"mode":"ojs"},{"id":1837,"value":"$3b","pinned":false,"hidden":false,"mode":"ojs"},{"id":1841,"value":"Metadata information:","pinned":false,"hidden":false,"mode":"md"},{"id":1845,"value":"viewof search_meta_adlbhy = Inputs.search(metadata_adlbhy)","pinned":false,"hidden":false,"mode":"ojs"},{"id":1848,"value":"viewof table_meta_adlbhy = Inputs.table(search_meta_adlbhy)","pinned":false,"hidden":false,"mode":"ojs"},{"id":1851,"value":"param_adlbhy = d3.groupSort(\n adlbhy,\n (g) => g[0].PARAM,\n (d) => d.PARAM.split(ablbc_split)[0]\n)","pinned":false,"hidden":false,"mode":"ojs"},{"id":21,"value":"---\n\n## Appendix","pinned":false,"hidden":false,"mode":"md"},{"id":24,"value":"subject_ids = d3.groupSort(\n adae,\n (g) => g[0].USUBJID,\n (d) => d.USUBJID\n)","pinned":false,"hidden":false,"mode":"ojs"},{"id":37,"value":"trt = d3.groupSort(\n adae,\n (g) => g[0].TRTA,\n (d) => d.TRTA\n)","pinned":false,"hidden":false,"mode":"ojs"},{"id":981,"value":"trt_ex = d3.groupSort(\n ex,\n (g) => g[0].EXTRT,\n (d) => d.EXTRT\n)","pinned":false,"hidden":false,"mode":"ojs"},{"id":1683,"value":"param_LBNRIND = d3.groupSort(\n adlbc,\n (g) => g[0].LBNRIND,\n (d) => d.LBNRIND\n)","pinned":false,"hidden":false,"mode":"ojs"},{"id":1400,"value":"ablbc_split = \" change from previous visit, relative to normal range\"","pinned":false,"hidden":false,"mode":"ojs"},{"id":1573,"value":"marginLeft = 320","pinned":false,"hidden":false,"mode":"ojs"},{"id":1022,"value":"colors = ({\n light_grey_2: \"#f3f4f4\",\n light_grey: \"#d0d3d4\",\n grey: \"#555\",\n black: \"#1c1c1c\",\n placebo: \"#a5a7aa\",\n drug_a: \"#3c0253\",\n drug_b: \"#886598\",\n ae_severity: { severe: \"#7e3433\", moderate: \"#f18070\", mild: \"#ffd482\" },\n indicators: \"#0a9ac6\",\n indicators_high: \"#005683\",\n indicators_low: \"#94d3ee\"\n})","pinned":false,"hidden":false,"mode":"ojs"},{"id":333,"value":"function getTrtName(name) {\n const newName = name.replace(/\\s+/g, \"_\");\n return newName.toLowerCase();\n}","pinned":false,"hidden":false,"mode":"ojs"},{"id":435,"value":"function parseDate(date) {\n const this_date = new Date(date);\n\n return this_date;\n}","pinned":false,"hidden":false,"mode":"ojs"},{"id":916,"value":"function produceBreaks(date_min, date_max) {\n const breaks = date_max < 90 ? 7 : 21;\n const ticks = Math.round((date_max - date_min) / breaks);\n\n const x_values = [];\n if (date_min >= 0) {\n for (var n = date_min; n <= ticks; n++) {\n x_values.push(n * breaks);\n }\n } else {\n console.log(date_min, date_max, ticks);\n let i = date_min;\n for (var n = 0; n <= ticks; n++) {\n x_values.push(Math.round(i / breaks) * breaks);\n i = i + breaks;\n }\n }\n\n return x_values;\n}","pinned":false,"hidden":false,"mode":"ojs"},{"id":1216,"value":"wrap = (elems) => {\n const div = document.createElement(\"div\");\n div.classList.add(\"wrap\");\n elems.forEach((el) => div.appendChild(el));\n return div;\n}","pinned":false,"hidden":false,"mode":"ojs"},{"id":1955,"value":"wrap_small = (elems) => {\n const div = document.createElement(\"div\");\n div.classList.add(\"wrap\");\n elems.forEach((el) => {\n const div_plot = document.createElement(\"div\");\n const para = document.createElement(\"p\");\n const node = document.createTextNode(el.title);\n para.appendChild(node);\n div_plot.appendChild(para);\n div_plot.appendChild(el.plot);\n div.appendChild(div_plot);\n });\n return div;\n}","pinned":false,"hidden":false,"mode":"ojs"},{"id":1321,"value":"function x_axis(date_min, date_max, x_values) {\n return {\n label: `Weeks →`,\n domain: [d3.min(x_values, (d) => d), date_max],\n ticks: x_values,\n clamp: true,\n tickFormat: (d) => d / 7,\n labelAnchor: \"center\"\n };\n}","pinned":false,"hidden":false,"mode":"ojs"},{"id":1450,"value":"$3c","pinned":false,"hidden":false,"mode":"ojs"},{"id":1930,"value":"$3d","pinned":false,"hidden":false,"mode":"ojs"},{"id":1894,"value":"$3e","pinned":false,"hidden":false,"mode":"html"}],"files":"$W3f","stdlib":"1","titling":"auto"}